Methods For Improving The Cellular Uptake Of Dna Origami...

†¢ Summary o The authors of this paper indicate an apparently novel method for improving the cellular uptake of DNA origami-based drug delivery nanocarriers. While the transport protein, transferrin (Tf), has been used to functionalize other types of drug delivery nanocarriers, it had yet to be incorporated into nanocarriers made via DNA origami prior to this publication. The authors demonstrate successful functionalization of Tf to a specific morphology of DNA origami using gel-shift analysis and atomic force microscopy; cellular uptake of the DNA nanocarriers was measured using quantitative polymerase chain reaction (qPCR) and confocal laser scanning microscopy (CLSM). The authors subsequently conclude a direct correlation between the†¦show more content†¦The seemingly small number of citations is only potentially problematic when considering the amount of research central to each term; it is difficult to believe that only a single source can accurately depict the ent irety of DNA-based computation, pH-sensors, molecular pegboards, or protein encapsulation. Additional sources may help demonstrate the potential importance and relevance of DNA-based nanostructures. o That being said, the number of citations referenced specifically when describing transferrin increases notably, which is important since transferrin is central to the paper while the terms mentioned in the previous bullet point are less immediately relevant. o Overall, the quality of citations appears to be sufficiently high, as does the quantity. This holds true especially when motivating the use of DNA and transferrin as constituent parts of a novel drug delivery platform. †¢ Novelty – The authors of this paper appear to demonstrate a novel functionalization for DNA origami-based drug delivery nanocarriers: transferrin. It is noted, however, that transferrin has been used as a targeting ligand in other forms of nanocarriers. Perhaps this detail should be more clearly stated to clarify that neither transferrin nor DNA origami are novel concepts, but rather their successful combination

Introduction of Event Marketing Free Essays

Introduction In the following, the feasibility analysis will define whether possible to organize the Game before 2030 in Hong Kong. game refers to the biggest multi-sport games after the Olympic game. There are 58 disciplines in this game. We will write a custom essay sample on Introduction of Event Marketing or any similar topic only for you Order Now Also, it is the biggest event in the Asian countries. This game is helped by the Olympic Council of China. They’re part of member organized the event every four years. (Olympic Council of China) Feasibility analysis 1. This event is a good idea Asian game can increase the awareness of sporting and the Hong Kong athletes can exchange the experience and communicate with another sport man/sport woman. It can improve the sporting infrastructure in Hong Kong and to meet the international standard of these sport equipments. Through the communication with other countries athlete, it can exchange the experience to gain more knowledge to perform the sport and the sport event well even to create the opportunity to organize another sport event to do so. Moreover, it can increase the importance of sport, to deliver the message of becoming a healthier person through sufficient physical exercise. It can increase the people’s willingness to doing exercise because they can know more about the sporty stuff via the Asian Game too. Samsung Distribution Channel iframe class="wp-embedded-content" sandbox="allow-scripts" security="restricted" style="position: absolute; clip: rect(1px, 1px, 1px, 1px);" src="https://phdessay.com/the-distribution-strategy-of-samsung/embed/#?secret=874mn943CC" data-secret="874mn943CC" width="500" height="282" title="#8220;Samsung Distribution Channel#8221; #8212; Free Essays - PhDessay.com" frameborder="0" marginwidth="0" marginheight="0" scrolling="no"/iframe This game can attract more tourists to come to Hong Kong to visit the event and to visit the many attractions here to raise the reputation on it. 2. We have the skills required to plan and run the event In the past, Hong Kong held 5th East Asian game successfully. (Agency for volunteer service) This organization helps to enroll the volunteers to involvement in the East Asian Game previously. It is important for us to organize the similar event like the Asian Games. Moreover, Hong Kong Leisure and Cultural Services Department organize amount of the sport event successfully in Hong Kong (Appendix 3) We have the experience in conducting the sport event like Hong Kong Seven. It enriches our experience in sports event. (Hong Kong Sevens) Moreover, in 2008, Olympic and Paralympics Equestrian Events also organized in Hong Kong successfully. Moreover, we can seek the Olympic Council to transfer experience and allocate the helpers and planners to us to facilitate the event. Asian Game since 1951 and it held 16 times so as to have many good examples to refer with. In this case, we can sure the necessary skills, knowledge and capabilities can be fulfilled through various sources to support with. 3. Community is supporting the Asian games There are two aspects to decide whether the community support. It refers to the government approvals and publicity efforts. Since we have enough skills, well-planning, and effective in allocating resources, it is not hard to get the government to approve this Asian Game. The supporting documents and evidence needs to submit to the government to get the permit. Before submitting to the government, we should seek the options of the residents who are nearing the event’s location. Normally, we need some helpers to collect the option of the residents, to conduct the survey with the citizen to persuade them to involve in this event. In this case, most of them will agree with the event because it is the international sport event and can enhance the reputation of Hong Kong. After the agreement of them, we need the publicity to help us to promote the event in a positive way to gain the government approve and support. 4. We have the infrastructure in the community The place that used to conduct the sport event is sufficient. There are many locations available to conduct the event. We can use the resources that are used in East Asian Games previously. Firstly, the Victoria park swimming pool is available to organize the swimming competition. Appendix 1) There have the parking space near the Swimming pool Also, it’s near the Tin Hau MTR station, have a bus stop on the Hing Fai Street (Appendix 2) In addition, there is Taxi stop, Mini bus stop , tram stops Near the MTR station. The audience of the swimming event can use these transportation tools to go and leave for the event. Moreover, there are lots of Leisure Facilities which are located in Hong Kong. (See Appendix 4) All of them have enough parking spaces, good transportation network, well-constructed roads and tracks, huge exhibition area, supplement of electronic power, water and heating and good as sewage treatment. . Can we get a venue at a price we can afford? According the Previous Press release, running a sport event used around 2. 4 billion and received around 1. 17 billion. We expected that the expenditure of Asian Games is 3. 4 billion and the revenue of 2. 17 billion. We can find sponsors to support the cost of decoration and catering to reduce the expenditure of the Asian Games. Moreover, the venue of the competition has a regular period to maintain the quality of the venue and the equipment in order to achieve the international standard requirements. We need to gain the safety teams to help to dialogues the sport person’s safe. St John is mainly responsible for the large scale of different kinds of event. It keeps to providing the first aid service in Hong Kong. (Please refer to Appendix 6) The venue manager is important when running the event, also, it is a critical role to decide whether the event successful so that he is necessary to monitor the arrangement of the venue. 6. Will the event attract media support? The Asian Games event will attract media support because it has over 20 countries to join our event so that the media must broadcast the event two or from the country. Most of the promotion tools rely on the sport event time interval to charge higher prices so that the media will support this game. Most of the company will place heavy advertisement during this period to enhance the awareness of them so that the media will encourage that kind of event. Moreover, the media can enrich the information and to deliver to their audience, to shape the issue, to trigger the discussion of the event. Moreover, the media is more willing to support the government-based event because the government will place advertisement in different media periodically. Once the media help the government, the opportunity to place the advertisement or public release in the media will increase. 7. The event is financially viable There are many ways to raise the capital to cover the costs. The sponsorship is the key sources of capital. We can find different sponsors to help us to facilitate the event. Omega companies can take responsibility on timing service. FedEx can help to deliver the materials which are related to the sport event. HSBC can sponsor some part of our expenses. Nike can sponsor the clothes of the sport person. Samsung can support all of LED display monitors. Although is it a vast investment in this event, the raising capital is not hard to complete once it is well-arranged. Also, we can sell the souvenirs to enhance the revenue. Some of the audience prefer to buy in memory of this event or as a gift to others. 8. The event will attract audiences Through the media and community support, it is sure attracting audience interest. Added up the government, it enhances the involvement of citizens. Also, the sponsors will help us to spread out the information about the event. Moreover, it is an international event in Hong Kong which it only once upon a time so that it is the selling point of this event. People can see the sport man who are coming from different and not coming before the event. The Uniqueness of this event is attractive for the audience. It brings benefits for the audience to observe the performance of them which is coming from various countries. 9. The success criteria are reasonable We can referring the past experience of organizing with the event and believe that this event is very attractive for the audience and the community, edia, government and sponsors will support us because it bring a lot of benefits for them. Enhance the awareness of them is a good example to illustrate this situation. Also, we are financially affordable, it enhance the opportunity for success as well. We can deliver the importance of sporting to the Hong Kong’s citizen success through the tools that mentioned above so that it is possible to gain success. The purpose of communicating with the sport man/woman is achieved in this event. Exchange the experience of against the competition also useful for them. 10. What are the risks? There have risks when running the event. It refers to the management risk and weather risk. Firstly, it is difficult to sure that all things are in control. It should have many meetings to communicate with a different department to maintain the consistency of the direction. Secondly, the weather is difficult to predict with 100% accurately so that is should provide other alternatives and to plan the arrangement of delay on competition. Conclusion To conclude, this event is worthy to start with because it brings a lot of long term benefits to the worldwide so that it should be going to run the event. How to cite Introduction of Event Marketing, Papers

Criminology Companion to Social Policy

Question: In each case study you must assume the role of a specific professional dealing with the case. Case studies are designed to reflect real life scenarios that you may encounter in human services professions. Answer: Introduction Presently the use of psychology or psychiatrist in order to solve the problems of criminal offense has been increased as it has immense importance in solving a criminal case by detecting the motive of the criminal, what was the criminals psych, state of mind at the time of performing any criminal activity is most important. What influence a criminal to perform crime is most important and it help in solving a case. There are many social service organizations, which works for the rehabilitations of the criminals who want turn their life around and want to lead normal life (Crank, 2011).. In the undertaken case study, it has been perceived that Alicia a volunteer mentor for a NOMS and ESF is working in a partnership with NPT. She has been matched to a participant named Richard in order to help him to find a job via ETE a department of NPT. Richard have many past criminal cases like he possessed cocaine and indulge in burglary but now he want to change his direction of life. Alicia is he lping him to do so. Main body Address the needs of the client Richard The needs that the client are being addressed in this case provides the detailed view of the explanation of the conditions with thereby the consideration have been made as per viewing the family conditions (Clinks, J, M., 2014). The vital need for Richard is the care and the nurturing that seems that these two things have not been provided to the client and thereby the structure of the needs have been crucially defaulted by the case. It thereby leads client to keep his legs in the world of the criminology and thereby the conditions have been worsted for the family with the separation of the father and the mother in the family. This case study also provides the overall view of the conditions of the client Richard and with previewing the present and the past conditions, the NAT provided the instructions in the form of the agreements that helped him to stay away from the world of the criminology. It also helped him to stay away from the bad influences that have been created for him with the consideration of funding issues. The funding issues become the vital issues in this case for the creation of the consideration for the client and thereby the client needs supports from its colleagues to come back to the right path (Guerrero, 2009). Appropriate rehabilitation programs must be arranged for the client Richard to get back the mental strength with the creation of the appropriate plan for the building a bright future for Richard. These are the crucial needs that are addressed to the client Richard for the removal of the colour racism distinction in the society and thereby the justice can be created for the client Richard. These factors created offence in the society with which the client is seemed to be have a segregated mind with the creation of distinction of the racism in the society and thereby the accessing services of the human rights becomes an issue (Shepherd, 2015). These facts and the figures help in the creation of the enhancements of the society and there by the issues can be resolved with the creation of the appropriate system of the alignment for the creation for the creation of the satisfaction for the client with understanding the values and the needs of the client. It also helps in the creation of the appropriate addressing of the issues for the client and thereby providing the ways for the creation of the legal atmosphere with support for the client Richard. Outline of the role and responsibility of the specific professional dealing with the case The criminal activity of Richard should be analysed in order to help him out of those activities. Richard is doing offensive things which should be checked Australia Federal Police. Australia Federal police play an important role in indentifying crime in the community and showing right path to t he criminals. The criminal activities generate profits for the offenders and it causes significant financial losses to the people of the community and Australian government. The Australian Federal police take steps in order to prepare an individual a good citizen such as allocating them jobs in the jail and keeping them in strict rules and regulations (Newburn, Tim. 2012). It is important for the government to take steps in order to reduce criminal activities in the nation. The organizations help the criminals and show them the right path by implementing right steps and technique. The Australian National Security also ensures peace in the nation by reducing the criminal activities in the nati on. The human right commission also play an important role in giving the right direction. The organizations can help Richard for not doing offensive things by suggesting them that it is not good and affects the community (Hylton, J. 2015). The Australia institute of crminilogy can also support Richard and helping him to be a good citizen. Conclusion In order to change the life of the criminal and their perception of life, the society has to take care of the criminals properly. There are several social service organizations, which provide necessary support and services to the criminal to change their life and come back to the main stream of life. Proper guidance and assistance help them to come back to the main stream of life. Here in the case Alicia the social service worker helps Richard to come back to his normal life. References Hylton, J. (2015) The journey ofdeveloping andapplying a one-to-one structured supervisionprogramme aimed ataddressing offendingbehaviour, Probation Journal, 62(1), pp.20-32. Newburn, Tim. (2012) Criminal Justice, in Alcock, P., May, M., Wright, S. (eds.) The Students Companion to Social Policy. 4th edn. Chichester: John Wiley and Sons pp. 366 - 373 Crank, B. (2011). Book Review: Hidden Truth: Young Men Navigating Lives In and Out of Juvenile Prison.Criminal Justice Review, 36(4), pp.514-516. Guerrero, G. (2009). Book Review: Harvey, J. (2007). Young Men in Prison: Surviving and Adapting to Life Inside. Collumpton, UK: Willan, 212pp.International Criminal Justice Review, 19(2), pp.249-250. Shepherd, B. (2015). Improving outcomes for young black and/or Muslim men in the CJS.Probation Journal, 62(2), pp.181-183. Clinks, J, M. (2014) The Young Review. Improving outcomes for young black and/or Muslim men in the Criminal Justice System: final report. Available at: https://www.youngreview.org.uk/ (accessed 16 February 2016)

The Future Of The Economy In The Year 2000 Essays -

The Future Of The Economy In The Year 2000 The economy has performed exceptionally well for the past several years, combining rapid growth and very low unemployment with declining inflation. ?Not only has the expansion achieved record length, but it has done so with far stronger growth than expected,? stated Federal Reserve Chairman Alan Greenspan in his remarks to the National Community Reinvestment Coalition annual conference in Washington (Business Week, The McGraw-Hill Companies, Economic Outlook, March 6,2000). Figures show that since 1996, the growth of GDP has averaged more than 4 percent, compared with an average of about 3 percent since 1973. Because of those four years of rapid growth, the unemployment rate has fallen to 4.1 percent, its lowest level since January 1970. Consumer Price Index (CPI) inflation, excluding food and energy prices, had been vacillating at about 3 percent per year earlier in the decade but was roughly 2 percent over the past year (Bank of America, Economic in Brief, November 1, 1999). Much of the auspicious recent economic developments can be attributed to a surge in productivity growth. Alan Greenspan noted in his statement that output per hour in the non-financial corporate sector had increased since 1995 at nearly double the average pace of the preceding 25 years (First Union, Monthly Economic Outlook, March 7, 2000). This rapid productivity growth allowed the economy to grow at a faster pace without raising the rate of inflation. However, the growth of consumer demand is exceeding the increase of productivity?boosting employment, tightening labor markets, and raising concerns that recent growth rates may not be sustainable without sparking a rise in inflation. After spending the past several years, extolling the virtues of improved productivity in allowing higher growth with less inflation, the Federal Reserve Chairman, seemed to turn the tables in his Humphrey Hawkins testimony, stating that the spurt in productivity has produced expectation of higher profit growth, which, in turn, have resulted in higher equity valuations. That surge in equity prices is seen as the primary driver of the ?wealth effect?, which he believes has created an ?imbalance? between demand and supply, raising inflation pressures (Business Week, The McGraw-Hill Companies, Economic Outlook, March 6,2000). Speculations of this occurrence may over the long term indicate that the higher the trend growth of productivity, the lower the inflation rate?due to the restraint of labor costs. However, in the short-run, if productivity growth jumps rather quickly to a higher level, its impact on demand would outrun the existing supply of recourses to meet that demand. Since supply cannot be increased quickly enough, Alan Greenspan believes demand growth must be brought back into line with supply growth. The mechanism to achieve a balance, he believes, is higher interest rates. High interest rates have, in fact, dampened home sales, but the overall economy has not cooled enough to reduce inflationary fears. The Fed is still concerned that strong consumer spending will lead to inflation. Right now, much of the strong demand is being satisfied by imports and expanded U.S. production from increased employment (Bank of America, Economic Research, Economic in Brief, November 1, 1999). Nevertheless, the Fed is worried that there may be limits to employment growth or foreign willingness to hold U.S. dollars earned exporting to the United States. Fed policymakers would be much more comfortable if the demand for goods would slow, thereby reducing the risk of the economy overheating or the dollar falling. Recent increases in the price of oil have reached their highest level since the Gulf War, and further increases could hurt U.S. economic growth. OPEC's decision to cut production last March has lead to rising inflation last year. Considering the most recent leap in oil prices, inflation reports in the near future could be strong, pushing the twelve-month CPI rate up to 3 percent or more (Business Week, The McGraw-Hill Companies, Economic Outlook, March 6,2000). The question of whether to maintain the status quo or increase production remains in the hands of OPEC members. At present, Saudi Arabia and Iran appear to favor increasing production, but some other constituents want to extend the production cuts. OPEC is likely to announce specific production plans at its next meeting on March 27. In